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GLP-1 pills: Wegovy pill vs Foundayo

There are now two FDA-approved GLP-1 pills for weight loss: the Wegovy pill from Novo Nordisk and Foundayo (orforglipron) from Eli Lilly.

Updated October 2026

Wegovy pillFoundayo
DrugOral semaglutideOrforglipron (small-molecule GLP-1)
US launchJanuary 2026April 2026
How to takeOnce daily, empty stomach, small sip of water, wait 30 minutes before eatingOnce daily, no food or water restrictions
Average weight loss in trials~14% (~17% in people who stayed on it)~12% at top dose
Cash price~$149–$299/mo by doseFrom $149/mo
Where to get itNovoCare, Ro, Hims & Hers, GoodRx, WW, retail pharmaciesLillyDirect, Ro, GoodRx and others

Pill or injection?

Injections still produce somewhat more weight loss on average. Pills suit people who dislike needles or want a cheaper starting option. Foundayo is easier to take; the Wegovy pill produced slightly more weight loss in trials.

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GLP1Rated is for general information only and is not medical advice. GLP-1 medications are prescription drugs with real risks and side effects. Talk to a licensed clinician before starting, stopping or changing any medication or supplement.

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